Please use this identifier to cite or link to this item: https://idr.l3.nitk.ac.in/jspui/handle/123456789/11520
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dc.contributor.authorOruganti, M.
dc.contributor.authorPallepogu, R.
dc.contributor.authorTrivedi, D.R.
dc.date.accessioned2020-03-31T08:35:17Z-
dc.date.available2020-03-31T08:35:17Z-
dc.date.issued2014
dc.identifier.citationJournal of Chemical Sciences, 2014, Vol.126, 5, pp.1291-1302en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/11520-
dc.description.abstractSix new salts of an API intermediate 2-aminothiazole with different carboxylic acid coformers were synthesized and characterized by IR (Infrared spectroscopy), 1H-NMR, DSC (Differential scanning calorimetry), XRPD (X-ray powder diffraction) and single crystal XRD. The crystal structure of the salts with benzoic acid, 2,3-, 2,4-, 2,5-, 2,6- dihydroxybenzoic acids and 2,4-dinitrobenzoic acid were determined. The thiazole moiety exhibited solvent (polarity) assisted tautomerism in all reported salts and proton transfer was noticed to the ring N of thiazole due to which two point supramolecular synthon N+-H(thiazole)?O-(acid), N-H(amine)?O-(acid) was observed. The crystal structures were studied with respect to the positional effect of the competing functional groups like hydroxyl (-OH) and nitro (-NO2) as well as their donor and acceptor abilities for hydrogen bonding. The presence of the non-conventional hydrogen bond (C-H?O) has been found to play a critical role in the formation of secondary supramolecular architectures. 2014 Indian Academy of Sciences.en_US
dc.titleIdentification of robust synthon in the molecular salts of 2-aminothiazole with substituted benzoic acids: A case studyen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

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