Please use this identifier to cite or link to this item: https://idr.l3.nitk.ac.in/jspui/handle/123456789/12226
Full metadata record
DC FieldValueLanguage
dc.contributor.authorThomas, K.D.
dc.contributor.authorAdhikari, A.V.
dc.contributor.authorChowdhury, I.H.
dc.contributor.authorSumesh, E.
dc.contributor.authorPal, N.K.
dc.date.accessioned2020-03-31T08:38:49Z-
dc.date.available2020-03-31T08:38:49Z-
dc.date.issued2011
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2011, Vol.46, 6, pp.2503-2512en_US
dc.identifier.urihttp://idr.nitk.ac.in/jspui/handle/123456789/12226-
dc.description.abstractThree new series of quinoline-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines were synthesized through multi-step reactions. The required intermediate, [1-(6-methoxy-2-methylquinolin-4-yl)-1H-1, 2,3-triazol-4-yl]methanol (2) was prepared by treating 4-azido-6-methoxy-2- methylquinoline (1) with propargyl alcohol. Three different series of compounds were synthesized from this intermediate. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 2 was confirmed by X-ray crystallographic study. Further, the title compounds were evaluated for their in vitro anti-bacterial activity against five different bacterial strains and antimycobacterial activity against Mycobacterium tuberculosis H37Rv, Mycobacterium smegmatis (ATCC 19420) and Mycobacterium fortuitum (ATCC 19542). Title compounds, 6a, 6d, 6i, 6j, 7e, 10a and 10i were found to be active against Mycobacterium tuberculosis H37Rv strain and could be lead molecules of interest. 2011 Elsevier Masson SAS.en_US
dc.titleNew quinolin-4-yl-1,2,3-triazoles carrying amides, sulphonamides and amidopiperazines as potential antitubercular agentsen_US
dc.typeArticleen_US
Appears in Collections:1. Journal Articles

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.