An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition

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DC Field	Value	Language
dc.contributor.author	Bhat, S.I.
dc.contributor.author	Das, U.K.
dc.contributor.author	Trivedi, D.R.
dc.date.accessioned	2020-03-31T06:51:38Z	-
dc.date.available	2020-03-31T06:51:38Z	-
dc.date.issued	2015
dc.identifier.citation	Journal of Heterocyclic Chemistry, 2015, Vol.52, 4, pp.1253-1259	en_US
dc.identifier.uri	10.1002/jhet.2220
dc.identifier.uri	http://idr.nitk.ac.in/jspui/handle/123456789/9878	-
dc.description.abstract	An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. 2014 HeteroCorporation.	en_US
dc.title	An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition	en_US
dc.type	Article	en_US
Appears in Collections:	1. Journal Articles

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