Please use this identifier to cite or link to this item: https://idr.l3.nitk.ac.in/jspui/handle/123456789/9878
Title: An Efficient Three-component, One-pot Synthesis of Quinazolines under Solvent-free and Catalyst-free Condition
Authors: Bhat, S.I.
Das, U.K.
Trivedi, D.R.
Issue Date: 2015
Citation: Journal of Heterocyclic Chemistry, 2015, Vol.52, 4, pp.1253-1259
Abstract: An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed. 2,4-Disubstituted quinazolines have been synthesized from three-component one-pot reactions of 2-aminoaryl ketones, orthoesters, and ammonium acetate. The present method has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time. The plausible mechanism of the reaction has been proposed based on the spectral characterization and single crystal X-ray analysis of isolated intermediate. 2014 HeteroCorporation.
URI: 10.1002/jhet.2220
http://idr.nitk.ac.in/jspui/handle/123456789/9878
Appears in Collections:1. Journal Articles

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